IL-4 and IL-13, But Not IL-10, Protect Human Synoviocytes from Apoptosis
نویسندگان
چکیده
منابع مشابه
Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Interleukin-4, which has been contemplated for the treatment of rheumatoid arthritis and/or osteoarthritis because of its anticatabolic properties, has also been shown to modulate apoptosis. Because inadequate apoptosis is thought to contribute to synovial hyperplasia, we have investigated the ability of IL-4 and other Th2 cytokines to protect human synovial cells from apoptosis. Human synovioc...
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We have recently reported that excessive synthesis of proinflammatory cytokines such as interleukin-6 (IL6) and IL-8 may play a role in the pathogenesis of mesenteric infarction. IL-4, IL-10 and IL-13 are classified as anti-inflammatory cytokines because they reduce the secretion of proinflammatory cytokines by stimulated monocytes/macrophage. During several inflammatory states anti-inflammator...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2001
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.166.4.2775